Champions Bayern Munich demolished VfB Stuttgart 4-0 on Saturday with all the goals coming in the first half as they increased their lead to eight points and stayed on course for a record fourth consecutive title on a day of red cards in the Bundesliga.
Pierre-Emerick Aubameyang scored twice as a rejuvenated Barcelona gave a football masterclass to inflict a humiliating 4-0 defeat on rivals Real Madrid on Sunday.
Harry Kane's injury-time goal gave England a 2-2 draw after a crazy finish to their World Cup qualifier against Scotland on Saturday with Leigh Griffiths having struck twice for the home side in the final three minutes.
PSG made hard work of beating Strasbourg 4-2 in the French Ligue 1, while Real Madrid registered a comfortable 4-1 win away to Alaves in their opening game.
Round-up of football matches played around Europe on Saturday.
In what was a thrilling match of end to end action, Germany powered past Ukraine by a 1-0 margin in their Euro 2016 Group C campaign-opening match in Lille on Sunday.
News of all that's transpired on and off the football field
Cristiano Ronaldo's fifth Champions League hat-trick inspired Real Madrid to a 3-0 comeback victory over VfL Wolfsburg on Tuesday that clinched a place in the semi-finals for a sixth successive season.
Borussia Dortmund's Marco Reus scored twice in a 3-1 victory at Werder Bremen on Saturday to put them within five points of Bundesliga leaders Bayern Munich while Borussia Moenchengladbach continued their sensational winning run with a 4-1 demolition of Hertha Berlin.
Juventus appear to be suffering from a predictable early-season slump in the wake of a summer spent fumbling around the transfer market in a bid to rebuild a team that had grown to dominate Serie A.
Spain forward Ansu Fati became the national team's youngest ever goalscorer as the 17-year-old inspired Luis Enrique's side to a resounding 4-0 win at home to Ukraine in the UEFA Nations League on Sunday.
Schalke 04 halted the Chelsea juggernaut when they drew 1-1 in their Champions League Group G opener at Stamford Bridge on Wednesday, handing a wake-up call to the London club who had won their first four games of the season.
Five-times European champions Barca, with their trident of Lionel Messi, Luis Suarez and Neymar subdued, have not exited in the last 16 since going out to Liverpool in the 2006/07 season and the score equalled their worst Champions league loss.
News of all that's transpired on and off the football field
Portugal had to settle for a 0-0 draw at home to Spain in a heavyweight friendly on Wednesday after hammering the crossbar twice and missing a last-gasp open goal.
Germany were stunned 1-0 by Mexico in the opening game of their World Cup defence on Sunday as Hirving Lozano finished off a sharp counter-attack that exposed the ragged defending that the four-times winners had displayed in their warm-up games.
Barcelona completed one of the most extraordinary comebacks in European football history to knock Paris St Germain out of the Champions League on Wednesday with a 6-1 victory that rewrote the record books.
News of all that transpired on and off the football field.
The good news for Schalke 04's defenders as they prepare to face Chelsea in their opening Champions League Group G match on Wednesday is that striker Diego Costa is nursing a slight hamstring injury.
Ten of the 16 sides also reached the same round two seasons ago and, as usual, the big five leagues dominate with 13 clubs hailing from either the English, Spanish, German, French and Italian leagues.
News of all that's transpired on and off the football field.
Barcelona forwards Ousmane Dembele and Lionel Messi fired the Catalans to a confidence-boosting 2-0 win at in-form Sevilla on Saturday to keep the pressure on La Liga leaders Atletico Madrid.
News of all that's transpired on and off the football field
VfL Wolfsburg reached the Champions League last 16 and dealt a knockout blow to Manchester United with a 3-2 victory to claim top spot in Group B and condemn their opponents to the Europa League on Tuesday.
Germany eased into the Confederations Cup semi-finals with a 3-1 win over Cameroon on Sunday as the VAR system was again thrust into the spotlight when the on-field official needed two reviews of an incident to reach the right verdict.
Gareth Southgate's plea for England to play with adventure and style was answered only fitfully as his reign as caretaker manager began with a 2-0 win over Malta in a World Cup Group F qualifier on Saturday.
Barcelona snapped a four-match winless run in La Liga with a 4-2 home victory over title rivals Sevilla on Saturday to reclaim top spot but the triumph was marred by talisman Lionel Messi fracturing his arm and being ruled out for three weeks.
News of all that's transpired on and off the football field
News of all that's transpired on and off the football field
A round-up of Saturday's matches in Ligue 1, Serie A and Bundesliga.
Second half goals from Presnel Kimpembe and Kylian Mbappe gave the impressive French side a clear advantage ahead of the return in Paris on March 6.
Real Madrid's Cristiano Ronaldo was the scourge of AS Roma again as he inspired the hosts to a 2-0 win and a place in the Champions League quarter-finals on Tuesday, scoring and setting up a goal Rodriguez to seal a 4-0 aggregate victory.
News of all that's transpired on and off the football field
Mario Mandzukic and Nikola Kalinic grabbed hat-tricks as Croatia achieved a record win as an independent nation by demolishing San Marino 10-0 in their final Euro 2016 warm-up match in Rijeka.
News of all that's transpired on and off the football field.
News of all that's transpired on and off the football field
News of all that's transpired on and off the football field
World champions Germany cruised to a comfortable 4-1 victory over Azerbaijan to stay on track for a spot in next year's World Cup in Russia, while England laboured to a 2-0 victory over Lithuania.
Images from the Champions League football matches played on Wednesday night.
Lionel Messi scored a penalty for the third Champions League game in a row with the Spaniards maintaining their winning start to the group stage.